Urinary Polypeptides

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This test analyses urine for diet-derived peptides (protein break down products) that may contribute to imbalances in conditions such as autism, ADD, ADHD, depression, and schizophrenia as total urinary peptides are globally associated with an increase in neurologic and psychiatric imbalances.

Foods and Autism

Parents have observed that certain foods appear to exacerbate symptoms of autism. It has been determined that symptoms particularly arise from proteins, including gluten (from wheat and other cereals) and casein (derived from milk). Some of the peptides obtained from gluten and casein are very similar to endorphins found in the brain and there for have an effect..

Treatment options involve diet, supplementation and eradication of intestinal irritants.

The Effect of Intestinal Permeability

Polypeptides circulating in the bloodstream are found in the urine of children (and adults) with neuro-psychiatric problems. This can be a consequence of increased intestinal permeability, sometimes referred to as “leaky gut” which increases the passage of peptides through the gut and into the blood stream due to

• Infection
• Dysbiosis
• Parasites
• Yeast overgrowth
• Food allergies
• Nutritional deficiencies causing damage to the intestinal lining

There are four basic types of urinary polypeptides measured

1. Indolyl-acryloylglycine
2. (IAG) – a metabolic by product of tryptophan. Serotonin uptake stimulators, peptides that decrease serotoninergic energy
3. Hyperkinese peptides recently discovered urinary peptides associated with ADHD
4. Exogenous morphine – like compounds – opioid peptides derived from food.

Increased levels in urine and serum are associated with increased rates of autism, schizophrenia, and some forms of despression. They are derived from:

• Gluten (wheat)
• Gliadin
• Casein (milk)

List of the urinary polypeptides

• Indolyl-3-acryloylglycine (IAG)
• Hyperkinese Peptide 1 (HK1)
• Hyperkinese Peptide 2 (HK2)
• Serotonin Uptake Stimulators
• Gluten Derivated Peptides I, II, III
• Glutemorphin A4, A5, B4, B5, C
• Gliaidinomorphin
• Bovine -casomorphin 1-4
• Bovine -casomorphin 1-4, amide
• Bovine -casomorphin 1-5
• Bovine -casomorphin 1-5, amide
• Bovine -casomorphin 1-7
• Bovine -casomorphin 1-8
• Human Casomorphin (1-4)
• Human Casomorphin (1-7)
• Urine Creatinine

Specimen Requirements

1 first thing in the morning urine sample

See instructions inside test kit for details

Before Taking this Test

Specimen must be collected Monday to Thursday

Turnaround time

18 days